产品货号：
GS4406
中文名称：
重组小鼠IL-10
英文名称：
Recombinant Murine Interleukin-10
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 18.7kDa,a single non-glycosylated polypeptide chain containing 160 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-10(IL-10)is encoded by the IL10 gene and expressed in monocytes and Type 2 T helper cells(Th2).The biological activities of IL-10 are mediated by the IL-10 receptor complex,which is composed of the ligand-binding IL-10 Rα/R1 and the accessory IL-10 Rβ/R2 subunits.IL-10 is capable of inhibiting the synthesis of a number of cytokines,including IFN-gamma,IL-2,IL-3,TNF and GM-CSF produced by activated macrophages and by T helper cells.IL-10 is classified as a class 2 cytokine which consist of IL-10,IL-19,IL-20,IL-22,IL-24 and IL-26,several interferons and interferon-like molecules.Mature murine IL-10 shares 70%-77%amino acid sequence identity with human,bovine,porcine IL-10,but murine IL-10 does not act on human cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠IL-10，IL-10, Murine，Recombinant Murine Interleukin-10
储存条件：冷冻（-20℃）
概述
Interleukin-10(IL-10)is encoded by the IL10 gene and expressed in monocytes and Type 2 T helper cells(Th2).The biological activities of IL-10 are mediated by the IL-10 receptor complex,which is composed of the ligand-binding IL-10 Rα/R1 and the accessory IL-10 Rβ/R2 subunits.IL-10 is capable of inhibiting the synthesis of a number of cytokines,including IFN-gamma,IL-2,IL-3,TNF and GM-CSF produced by activated macrophages and by T helper cells.IL-10 is classified as a class 2 cytokine which consist of IL-10,IL-19,IL-20,IL-22,IL-24 and IL-26,several interferons and interferon-like molecules.Mature murine IL-10 shares 70%-77%amino acid sequence identity with human,bovine,porcine IL-10,but murine IL-10 does not act on human cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine MC/9-2 cells is less than 1ng/ml,corresponding to a specific activity of>1.0×106 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rMuIL-10 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in 10mMHCl to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | SRGQYSREDN NCTHFPVGQS HMLLELRTAF SQVKTFFQTK DQLDNILLTD SLMQDFKGYL GCQALSEMIQ FYLVEVMPQA EKHGPEIKEH LNSLGEKLKT LRMRLRRCHR FLPCENKSKA VEQVKSDFNK LQDQGVYKAM NEFDIFINCI EAYMMIKMKS |
相关搜索：重组小鼠IL-10，IL-10, Murine，Recombinant Murine Interleukin-10